A lonely and grown‑up Peter Parker devotes himself entirely to fighting crime in New York, since four years ago, after Doctor Strange’s spell, the world and all his loved ones forgot about him. But as the threats and the burden on Spider‑Man grow, his abilities undergo strange changes that could jeopardize his very existence. Meanwhile, a new series of crimes unfolds in the city, leading to the emergence of one of the most dangerous adversaries in Peter’s life.