While investigating the details of the unknown killer's bloody deeds, Detective Eric Matthews realizes that they bear a striking resemblance to the work of the Jigsaw Killer, a notorious serial killer who managed to elude capture, leaving behind a trail of victims. Matthews' suspicions are confirmed when the Jigsaw Killer resumes his gruesome activities. However, this time, instead of targeting two individuals, the Jigsaw Killer locks eight people in a death chamber, with only one way out. Eight strangers are forced to engage in a game of survival against a deranged killer, with their lives as the stakes.