Adaline Bowman is a 100-year-old young woman who was born in 1908. After a car accident and a lightning strike in 1937, she stopped aging. Every ten years, she changes her identity, documents, job, and surroundings. Her only constant companions are her aging daughter, a blind pianist friend who doesn't know Adaline's age, and her tenth dog of the same breed. One day, during a New Year's Eve celebration, Adaline meets a handsome young man named Ellis, who makes her want to stop running away.