A world where demons feed on humans without their knowledge. Once upon a time, the most powerful demon was defeated, and its body parts were scattered across the world. The one who can collect and consume them will gain unlimited power and even the ability to destroy humanity. Yuji Itadori, a physically fit high school student, is preoccupied with his grandfather's health, spending most of his time in the hospital. To escape the constant offers to join sports clubs, he enrolls in an occult club. However, he finds himself at the center of a battle for human destiny when his friends cast a spell on a magical artifact.